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Quotation mark shaped like a kidneyIt started with Ckd.

But my diagnosis

went Deeper.

But my diagnosis

went Deeper.

  But my diagnosis went Deeper.

 

 

 

 

For people of African ancestry, there may be a deeper diagnosis than chronic kidney disease (CKD). Learn more about APOL1-mediated kidney disease (AMKD), the APOL1 gene and African ancestry, and how to diagnose AMKD.
APOL1

One gene can pinpoint the diagnosis.
One test can inform the way forward.

 

Deeper Knowledge:

 

UNDERSTANDING
AMKD

 

AMKD is a rapidly progressive form of proteinuric
kidney disease.1,2

LEARN MORE

Deeper Look:

 

APOL1 AND AFRICAN
ANCESTRY

 

AMKD is caused by 2 variants of the APOL1 gene and a
second hit, and occurs in people of African ancestry.3,4

DISCOVER THE CAUSE

Deeper Dive:

 

DIAGNOSING AMKD

 

A definitive diagnosis of AMKD requires a genetic test for
APOL1 risk variants, so test your kidney disease patients of
African ancestry for APOL1 today.1

HOW TO DIAGNOSE

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References: 1. Freedman BI, Burke W, Divers J, et al. Diagnosis, education, and care of patients with APOL1-associated nephropathy: a Delphi consensus and systematic review. J Am Soc Nephrol. 2021;32(7):1765-1778. doi:10.1681/ASN.2020101399 2. Elliott MD, Marasa M, Cocchi E, et al. Clinical and genetic characteristics of CKD patients with high-risk APOL1 genotypes. J Am Soc Nephrol. 2023;34(5):909-919. doi:10.1681/ASN.0000000000000094 3. Friedman DJ, Pollak MR. APOL1 and kidney disease: from genetics to biology. Annu Rev Physiol. 2020;82:323-342. doi:10.1146/annurev-physiol-021119-034345 4. Friedman DJ, Pollak MR. APOL1 nephropathy: from genetics to clinical applications. Clin J Am Soc Nephrol. 2021;16(2):294-303. doi:10.2215/CJN.15161219

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